Frank C Tortella Selected Research

RS100642

10/2003	Neuroprotection assessment by topographic electroencephalographic analysis: effects of a sodium channel blocker to reduce polymorphic delta activity following ischaemic brain injury in rats.
4/2002	Neuroprotective effects of the sodium channel blocker RS100642 and attenuation of ischemia-induced brain seizures in the rat.

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Frank C Tortella Research Topics

Disease

50	Brain Injuries (Brain Injury) 01/2019 - 04/2002
39	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2019 - 08/2005
14	Seizures (Absence Seizure) 01/2022 - 04/2002
10	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 12/2009 - 04/2002
7	Inflammation (Inflammations) 01/2017 - 09/2002
7	Infarction (Infarctions) 12/2009 - 09/2002
6	Ischemia 01/2012 - 04/2002
6	Brain Ischemia (Cerebral Ischemia) 12/2009 - 05/2002
5	Neuroinflammatory Diseases 03/2016 - 08/2009
5	Wounds and Injuries (Trauma) 03/2016 - 08/2009
4	Hypoxia (Hypoxemia) 05/2014 - 05/2007
3	Brain Edema (Cerebral Edema) 03/2016 - 07/2011
2	Craniocerebral Trauma (Head Injury) 01/2015 - 01/2012
2	Edema (Dropsy) 05/2014 - 07/2011
2	Brain Concussion (Cerebral Concussion) 05/2014 - 05/2012
2	Penetrating Head Injuries (Penetrating Head Injury) 07/2013 - 07/2011
2	Hypoglycemia (Reactive Hypoglycemia) 07/2007 - 05/2007
2	Cerebral Infarction 09/2005 - 01/2004
2	Brain Infarction 05/2004 - 04/2002
1	Mental Disorders (Mental Disorder) 01/2021
1	Treatment-Resistant Depressive Disorder 01/2021
1	Gunshot Wounds (Gunshot Wound) 01/2017
1	Intracranial Hypertension 03/2016
1	Tauopathies 01/2016
1	Cognitive Dysfunction 01/2016
1	Multiple Trauma (Multiple Injuries) 08/2015
1	Hemorrhagic Shock 07/2013

Drug/Important Bio-Agent (IBA)

27	Biomarkers (Surrogate Marker)IBA 01/2019 - 01/2004
15	Pharmaceutical PreparationsIBA 01/2019 - 09/2005
12	Proteins (Proteins, Gene)FDA Link 01/2019 - 01/2004
11	Neuroprotective AgentsIBA 03/2016 - 04/2002
6	Glial Fibrillary Acidic ProteinIBA 01/2019 - 06/2012
6	CytokinesIBA 01/2017 - 09/2002
4	Ubiquitin Thiolesterase (Ubiquitin Carboxy-Terminal Hydrolase)IBA 01/2019 - 05/2012
4	Levetiracetam (Keppra)FDA LinkGeneric 01/2018 - 01/2016
4	Ubiquitin CIBA 01/2016 - 02/2010
4	Messenger RNA (mRNA)IBA 09/2013 - 09/2002
4	NNZ 2566IBA 09/2013 - 01/2009
4	glycyl-prolyl-glutamic acidIBA 09/2013 - 01/2009
4	Glutamic Acid (Glutamate)FDA Link 06/2013 - 05/2007
3	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2021 - 12/2003
3	Transcription Factors (Transcription Factor)IBA 05/2014 - 09/2002
3	VeratridineIBA 06/2013 - 05/2007
3	Adenosine Monophosphate (AMP)IBA 08/2012 - 11/2009
3	CalpainIBA 08/2006 - 01/2004
3	Proteasome InhibitorsIBA 07/2006 - 01/2003
3	NF-kappa B (NF-kB)IBA 07/2006 - 09/2002
2	N-Methylaspartate (NMDA)IBA 01/2021 - 05/2002
2	Therapeutic UsesIBA 01/2018 - 10/2015
2	Gabapentin (Neurontin)FDA LinkGeneric 01/2017 - 09/2006
2	Simvastatin (Zocor)FDA LinkGeneric 03/2016 - 01/2016
2	SpectrinIBA 01/2016 - 01/2004
2	Dextromethorphan (Racemethorphan)FDA LinkGeneric 10/2015 - 11/2009
2	salicylhydroxamic acid (SHAM)IBA 08/2015 - 12/2012
2	Protein Isoforms (Isoforms)IBA 05/2014 - 08/2006
2	Ethosuximide (Zarontin)FDA LinkGeneric 12/2013 - 09/2006
2	Oxygen (Dioxygen)IBA 07/2013 - 01/2012
2	EnzymesIBA 05/2012 - 06/2011
2	3-aminopyridine-2-carboxaldehyde thiosemicarbazone (triapine)IBA 07/2007 - 01/2006
2	StaurosporineIBA 07/2007 - 05/2007
2	Proteasome Endopeptidase Complex (Proteasome)IBA 07/2006 - 01/2003
2	Peptide Hydrolases (Proteases)FDA Link 03/2006 - 01/2004
2	conotoxin GVIBA 09/2005 - 05/2002
2	Sodium Channel BlockersIBA 10/2003 - 04/2002
2	RS100642IBA 10/2003 - 04/2002
1	EsketamineIBA 01/2021
1	poly(vinylpyrrolidone-co-vinyl-acetate)IBA 01/2018
1	Glyburide (Glibenclamide)FDA LinkGeneric 01/2018
1	Amantadine (Aman)FDA LinkGeneric 01/2018
1	MicroRNAs (MicroRNA)IBA 01/2017
1	Erythropoietin FDA Link 03/2016
1	CholesterolIBA 03/2016
1	Coenzyme A (CoA)IBA 03/2016
1	Cyclosporine (Ciclosporin)FDA LinkGeneric 03/2016
1	Niacinamide (Nicotinamide)FDA LinkGeneric 03/2016
1	Oxidoreductases (Dehydrogenase)IBA 03/2016
1	Amyloid beta-PeptidesIBA 03/2016
1	Amyloid (Amyloid Fibrils)IBA 01/2016
1	DeuteriumIBA 10/2015
1	Chondroitin Sulfates (Chondroitin Sulfate)IBA 08/2015
1	chondroitin 4-sulfotransferaseIBA 08/2015
1	N-Acetylgalactosamine-4-Sulfatase (Arylsulfatase B)IBA 08/2015
1	SolutionsIBA 01/2015
1	Aligeron (AS 2)IBA 01/2015
1	Aquaporin 4IBA 05/2014
1	Aquaporins (Water Channels)IBA 05/2014
1	Phenytoin (Dilantin)FDA LinkGeneric 12/2013
1	Interleukin-6 (Interleukin 6)IBA 09/2013
1	nefiracetamIBA 06/2013
1	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA 12/2012
1	SuspensionsIBA 08/2012
1	ImmunosorbentsIBA 05/2012

Therapy/Procedure

25	Therapeutics 01/2019 - 05/2004
4	Treatment Delay 12/2009 - 01/2003
3	Precision Medicine 01/2019 - 03/2016
2	Critical Care (Surgical Intensive Care) 01/2022 - 01/2011
2	Electrodes (Electrode) 05/2006 - 09/2005
1	Intravenous Administration 01/2016
1	Resuscitation 08/2015
1	Cell- and Tissue-Based Therapy (Cell Therapy) 08/2012